Protein Charge Calculator
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The Protein Charge Calculator helps determine the net charge of a protein sequence at pH 7 based on the presence of charged amino acids. Understanding protein charge is crucial for predicting solubility, stability, and interactions in biochemical contexts.
How the Calculator Works
- Amino Acids Considered: The primary amino acids with significant charges at pH 7 are aspartic acid (D), glutamic acid (E), lysine (K), arginine (R), and histidine (H).
- Charge Values: The approximate charges used are:
- D, E: -1
- K, R: +1
- H: +0.1 (partial charge due to side chain pKa)
Example Calculation
For a sequence like "DEKRH", the net charge would be: \[ \text{Net Charge} = (-1) + (-1) + (+1) + (+1) + (+0.1) = +0.1 \]
Applications and Importance
Calculating protein charge is important in protein purification, formulation, and structural biology, where charge influences how proteins behave under different conditions.